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Weill Bugando Medical Centre

Courtesy of Alina Shaw

Fellowship Site Directors:
Daniel Fitzgerald, MD, Robert Peck, MD

Site Contact:
Lindsey Reif

Site Specialties: HIV/AIDS, Clinical Trials, Chronic Diseases

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Site Highlights:

  • The relationship between Weill Cornell and Weill Bugando began over 20 years ago. A Weill Cornell faculty committee directed by Dr. Warren Johnson, coordinates educational exchanges between multiple Weill Cornell and Weill Bugando departments. These exchanges are supported by Weill Cornell Dean Antonio Gotto, The Touch Foundation, the Pfizer Foundation, and private donors.
  • The Weill Bugando Medical College in Mwanza, Tanzania opened in September 2004 and has been affiliated with Cornell University in New York since its inception. The college offers an MD training program, and a Masters in Medicine in Adult Medicine, Obstetrics and Gynecology, Pediatrics and Surgery, and graduate degrees in basic sciences. Weill Bugando’s main teaching hospital is the Bugando Medical Centre, a 900 bed tertiary referral hospital for the people of the Lake and Western regions of Tanzania.
  • In 2008, approximately 30 NYPH/Weill Cornell clinical residents visited Bugando to teach on the wards and conduct tutorials in internal medicine, pediatrics, obstetrics and gynecology, ophthalmology, psychiatry, and surgery.
  • Two full-time Weill Cornell faculty members, Dr. Robert Peck and Dr. Beatrice Im, are based at Weill Bugando to coordinate teaching and training of Bugando and Weill Cornell trainees. Dr. Peck, who will serve as one of Dr. Smart’s primary mentors, has been based at Weill Bugando for the past 5 years and directs the Cornell Program in Tanzania.
  • The goal of the Weill Cornell program in Tanzania is to support research, medical education, and clinical services in the city of Mwanza, Tanzania. Research is conducted in collaboration with the National Institute of Medical Research (NIMR), an internationally recognized center conducting epidemiologic studies and clinical trials on HIV, sexually transmitted infections, schistosomiasis, and chronic diseases. Cornell-NIMR research training focuses on interactions between HIV and schistosomiasis and on chronic diseases. Medical education and clinical services are provided with the Weill Bugando Medical College and teaching hospital.
  • Cornell University’s partner research, education, and clinical institutions in Mwanza Tanzania are the National Institute of Medical Research, Weill-Bugando Medical College, and Bugando Hospital. The research center, medical college, and hospital are located together in the city of Mwanza with shared facilities, resources, and faculty. Mwanza is a burgeoning hub of medical research and training with vast potential for growth.
  • The goal of the Weill Cornell program in Tanzania is to support research, medical education, and clinical services in the city of Mwanza, Tanzania. Research is conducted in collaboration with the National Institute of Medical Research (NIMR), an internationally recognized center conducting epidemiologic studies and clinical trials on HIV, sexually transmitted infections, schistosomiasis, and chronic diseases. Cornell-NIMR research training focuses on interactions between HIV and schistosomiasis and on chronic diseases. Medical education and clinical services are provided with the Weill Bugando Medical College and teaching hospital. The medical college has collaborated with Cornell since its inception in 2006 and graduated its first students in 2010. Dr Daniel Fitzgerald and Dr Warren Johnson co-direct the Cornell Tanzania program with two on site Cornell faculty (Dr Jen Downs, Dr Robert Peck). Weill Cornell research training is supported through a Fogarty AITRP program (TW00018; PI WD Johnson) and global health research training grant (AI098627; PI Fitzgerald).

    Medical College & Hospital:

    Weill Bugando Medical College is Tanzania’s only medical school in western Tanzania. The medical college was opened in 2003 and is located on a 52 acre campus on Bugando Hill in the city of Mwanza. The college was renamed in 2007 in honor of benefactors Joan and Sanford Weill, becoming the Weill Bugando Medical College, which now provides training for almost 400 medical students and 50 students in four Master of Medicine post-graduate programs (internal medicine, obstetrics and gynecology, surgery, pediatrics). The medical college has 60,000 square feet of teaching space including 2 large auditoriums, 12 classrooms, an anatomy dissection theatre, a teaching laboratory, faculty offices, and administrative space. Weill Bugando has a medical library that is approximately 5,000 square feet. The library has 6 staff members including chief librarian Mr. Yanga Machuma. The library currently has approximately 6,000 medical textbooks and 12 computer terminals with internet access. Weill Bugando also has access to over 7000 journals and PubMed via the World Health Organization’s HINARI program. Weill Bugando has living quarters and accommodations for faculty, residents, and students. There are 42 apartments on campus for senior faculty (12 three-bedroom, 24 two-bedroom, and 8 one-bedroom). There is also a guest house with 6 bedrooms for visiting faculty and trainees from WCMC.
    The Bugando Hospital is the consultant and teaching hospital for the western zones of the United Republic of Tanzania. Situated along the shores of Lake Victoria in Mwanza City, it is a 900-bed referral hospital that oversees medical care for approximately 15 million people living in the zone. It is a referral centre for tertiary specialist care for six regions, including Mwanza, Mara, Kagera, Shinyanga, Tabora, and Kigoma. The hospital and its on-campus clinics receive over 250,000 patient visits per year, with over 43,000 admissions per year. Additionally, Bugando has a very active outpatient HIV clinic that is the referral clinic for the entire Lake Zone.

    Bugando has eight buildings (A-H) interconnected with covered walkways. The main building is 11 stories; the first floor is dedicated to out-patient clinics. The second floor is administrative offices. The upper floors house patient wards with 900 beds. The basement houses 6 operating theatres. A 14,000 square foot clinical laboratory was recently renovated and relocated to a large wing of the hospital with support of the Abbott Fund, which has also renovated and improved several other critical laboratories in rural hospitals the Lake Zone region. The Abbott Fund also continues to support scholarships for Bugando’s laboratory technician students, assuring a supply of talented laboratory technicians to staff the Bugando and rural laboratories.The 24-hour/day hospital laboratory has sections for hematology, chemistry, serology, blood transfusion, parasitology, and microbiology. It houses the national tuberculosis laboratory for the region, and has capacity to perform multidrug resistant tuberculosis sensitivity testing. The laboratory has standard operating procedures for all assays and adheres to good clinical and laboratory practices.

    Departments and Laboratory Facilities:

    NIMR Facilities: The Tanzanian National Institute for Medical Research (NIMR), a governmental research laboratory with over 50 research scientists has conducted medical research in the Mwanza region for 30 years. NIMR scientists regularly participate in field work and community-based studies, including large epidemiological studies and clinical trials.

    The NIMR campus has three buildings. The first and oldest building is approximately 15,000 square feet and houses office and laboratory space for research scientists, statisticians, field workers, and parasitologists. The second building is the 4000 square-foot laboratory, as further described below. NIMR’s newest building was opened in July 2009, and is over 20,500 square feet. This building houses the core departments of Information and Communication Technology, Data Management and Analysis, Administration and Finance, and Laboratory Services. In addition, the building provides 35 offices for researchers and project teams, an entire wing for storage of clinical specimens and field data, conference hall facilities for 125 participants, a smaller training room that can accommodate about 40 people, and meeting rooms for up to 20 people. NIMR hosted its first international conference, entitled, “HIV Prevention—Where Now?” in July 2009.

    NIMR has developed three dedicated research clinics in the Mwanza region that are closely linked with rural health centers, each of which is under the clinical oversight of Bugando Hospital. These are now being used for conduct of the Phase IIIb randomized clinical trial of the GlaxoSmithKline Human Papillomavirus vaccine and for the conduct of chronic disease research such as hypertension and diabetes. The research clinics have the capacity for data storage, processing and storage of biological samples, clinical examinations, HIV testing and counseling, pharmacies, study supply storage, reception/waiting areas for study participants, and working rooms for study coordinators. In collaboration with local health workers, these clinics also provide general physical and pelvic examinations, cervical cancer screening and referrals, family planning, pregnancy testing and referrals to antenatal clinics, screening and treatment for sexually-transmitted infections, testing and treatment for malaria, and referrals for HIV care.

    The newly-built laboratory at NIMR was completed in 2003 with support from the Medical Research Council (United Kingdom) and the London School of Hygiene and Tropical Medicine (LSHTM). The facility has over 4000 square feet with eight air-conditioned rooms and dedicated rooms for hematology (full blood counts and CD4 differential counts by flow cytometry), biochemistry (full blood chemistry), serology (HIV, syphilis, Herpes simplex virus type 2), and molecular biology. The molecular biology section has the capacity to amplify DNA for Chlamydia trachomatis and Neisseria gonorrhoeae, to conduct monoclonal antibody-based ELISA tests, and to determine microorganism loads by real time PCR. It is equipped with two ABI thermocyclers, microcentrifuges, an ELISA reader, and a light cycler for real-time PCR. The lab also has two dedicated freezer rooms and one refrigerator room with a 44 KVA generator that has an automatic switch for power back-up to the laboratory.
    In addition, the laboratory is equipped with a Laboratory Information Management System (LIMS) for receipt, processing, and tracking of samples. Each section of the laboratory has its own computer terminal and bar-code scanner. All samples have bar-code labels, which are essential for the laboratory to maintain the chain of custody.

    The NIMR laboratory is capable of high-quality testing of up to 2000 samples per week with short turn-around time to support NIMR’s large epidemiological studies. The laboratory’s quality assurance is verified by Contract Laboratory Service (South Africa), the Centers for Disease Control (United States), the UK Quality Control for Molecular Diagnosis (United Kingdom), the AFREQUAS CD4+ Lymphocyte Proficiency Programme (South Africa), and the Royal College of Pathologists (Australia). Agreement between the NIMR laboratory and reference laboratories has been close to 100%.

    The NIMR Data Management and Analysis Department was established approximately 15 years ago, and in recent years has grown exponentially in proportion to the need created by the increasing volume of trials taking place at NIMR. In 2007, the Department was given an entire wing in NIMR’s newest building. The vision of the department is to participate actively in all phases of research project development. This includes design of data collection tools, tracking of participant recruitment and follow-up, converting data from paper to electronic form, and statistical analysis of data.

    The department’s new data management system, DMSys, is compliant with Good Clinical Practice (GCP) and US Food and Drug Administration (FDA) regulations. Staff in the department have been trained in the system’s use, and it has successfully been used to manage data for NIMR’s large clinical cohorts and epidemiologic studies. In the past year, the department has begun to implement the use of electronic devices for field data collection, which increases data processing capacity and minimizes transcription errors.

    The Data Management and Analysis Department consists of a senior data manager, a medical statistician, three junior data managers, a data archivist, and a team of eight data entry clerks. In addition, Dr. Jim Todd is a senior statistician and a faculty member at the London School of Hygiene and Tropical Medicine who is stationed full-time at NIMR. He plays a major role in statistical analysis of data and in mentoring junior staff with the goal of building capacity in this area.

    The newest building on the NIMR campus was opened in July 2009. In addition to the conference and training facilities, meeting rooms, and storage space described above, the building also has 35 offices, which can accommodate researchers, data managers and data entry staff, and statisticians. These offices are equipped with work stations that have internet access. All offices have access to a printer and copier as well.

    Research Training Facilities:

    Research Training Facilities: The NIMR center in Mwanza works closely with Weill Bugando Medical College and is dedicated to training young investigators and to building research capacity in the Mwanza region. NIMR has 30 senior investigators and a team of experienced laboratory technicians, data managers, and field workers. NIMR has had long-standing ties to the London School of Tropical Medicine and Hygiene. Dr. Fitzgerald has collaborated with NIMR researchers since 2006 with publications on natural history studies of HIV (AIDS, 2006), point-of-care syphilis diagnostics (STI, 2006) and HIV and schistosomiasis (Am J Trop Med Hyg, 2011). Collaborators include Dr. Saidi Kapiga, Mr. John Changalucha, and Dr. Jim Todd.

    NIMR has received numerous grants from sponsors including the Wellcome Trust, the European and Developing Countries Clinical Trials Partnership (EDCTP), the United Kingdom Department for International Development (DFID), and the United Kingdom Medical Research Council (MRC). The potential for ongoing collaboration with scientists at all levels within this organization is vast. Current research projects at NIMR include:

    Current and potential future research opportunities for Global Health Fellows:

    The Tanzama Project
    This is a 15 year longitudinal community based HIV surveillance program in rural villages in the Kissessa region of Mwanza, with a population of 30,000. The study is supported by the Wellcome Trust and the Global Fund against AIDS, TB, and Malaria. Every six months, study teams conduct community based demographic, medical, and sero-surveys in rural villages. Outcomes include HIV seroincidnce and risk factors for infection, natural history of HIV disease, vertical HIV transmission rates, and the impact of new HIV prevention and therapeutic interventions. Data are stored at a data management center in Mwanza and analyzed with the assistance of on-site demographers and statisticians. This is one of the longest HIV community based surveillance programs in Africa. Dr Fitzgerald is collaborating with NIMR to introduce a nested case-control study within the Tanzama Project to examine the effect of S. haematobium infection on HIV incidence in women of reproductive age.(Se Research Strategy section for details)

    Site Preparation for Trials of Vaginal Microbicides in Mwanza, Tanzania
    This project funded by the European and Developing Countries Clinical Trials Partnership (EDCTP) has the goal of preparing clinical sites and strengthening capacity for future microbicide trials in Tanzania. NIMR study team members have established two study clinic sites in mining communities and highway regions and have begun recruitment of 1000 HIV-negative women who are commercial sex documented to be at high risk for incident HIV. The project seeks to determine HIV seroincidence and to describe and quantify intravaginal practices (cleansing, inserting materials, lubricating, drying) taking place among Tanzanian women in the region that may be increasing the risk of HIV acquisition.

    Phase IIIb, Double-Blind, Randomized, Controlled, Multicenter Study to Assess the Immunogenicity and Safety of GlaxoSmithKline Biologicals HPV-16/18 L1AS04 Vaccine Administered Intramuscularly According to a Three-Dose Schedule in Healthy Female Subjects
    Also known as the GSK HPV-021 trial, this project funded by GlaxoSmithKline is evaluating antibody responses against HPV-16 and HPV-18 at month 7 in participants who are 10-14 years of age and 15-25 years of age. Subjects are healthy girls and young women from schools, colleges, and family planning clinics in the Mwanza town, randomized 2:1 to receive placebo or vaccine.

    Uptake and Cost-Effectiveness Rapid Syphilis Testing in Antenatal Care and the Feasibility of its Integration into Prevention of Mother-to-Child Transmission of HIV Programs in Tanzania
    This study is supported by the Bill and Melinda Gates Foundation through the World Health Organization Special Program for Research and Training in Tropical Diseases. Dr Fitzgerald is a co-investigator with participation in Haiti and Tanzania. The project will determine feasibility of increasing access to antenatal syphilis screening using a same-day testing and treatment strategy. The study will also explore cost-effectiveness of introducing quality-assured rapid syphilis screening into existing Prevention of Mother to Child Transmission and other antenatal services

    Community Based Surveillance for Chronic Diseases
    This is a community based field study to determine the epidemiology of chronic diseases in Tanzania funded by The Medical Research Council. The PI is Saidi Kapiga and collaborators include Dr Robert Peck (WCMC).The major chronic diseases studied are hypertension, diabetes, chronic obstructive pulmonary disease, chronic kidney diseases, and depression. 600 randomly selected adults will be enrolled from 5 different locations, (2 sites in the city, and 3 sites in rural areas).